Chronic stress is rarely a single-ingredient problem — and Tranquilix Cortisol Complex was designed with that reality in mind. Where most stress supplements pick one or two adaptogens and call it a formula, Tranquilix Cortisol Complex layers eight clinically supported ingredients across four distinct physiological systems: the HPA axis (cortisol regulation), the nervous system (neurotransmitter balance), cognitive performance (memory and mental clarity), and nutritional support (B vitamin and mineral replenishment depleted by chronic stress).

The 8-Ingredient Cortisol Protocol

Ashwagandha Root Extract (KSM-66®) — 300mg The anchor of the formula. KSM-66® is the world's most clinically studied ashwagandha extract, shown in multiple randomized controlled trials to significantly reduce serum cortisol, lower perceived stress scores, and improve sleep quality in chronically stressed adults. At 300mg in a multi-ingredient matrix, it delivers meaningful adaptogenic support without overwhelming the formula.

Rhodiola Rosea Extract (3% rosavins) — 200mg A Scandinavian and Siberian adaptogen with centuries of use in high-stress military and high-altitude environments. Standardized to 3% rosavins — the active compound class — rhodiola has been clinically shown to reduce mental fatigue, improve endurance under stress, and support emotional resilience. It works synergistically with ashwagandha to address both the physical and mental dimensions of stress load.

Phosphatidylserine (from sunflower) — 100mg A phospholipid naturally found in brain cell membranes, phosphatidylserine is one of the only supplements with an FDA-qualified health claim related to cognitive function. Research shows it directly blunts the cortisol response to physical and psychological stress, while simultaneously supporting memory consolidation, attention, and processing speed — making it especially valuable for professionals experiencing cognitive stress symptoms.

L-Theanine — 150mg Green tea's calming amino acid promotes alpha brain wave activity and reduces stress perception without sedation. At 150mg it synergizes with rhodiola to smooth out mental tension and restore focused calm.

Lemon Balm Extract (10:1) — 150mg A member of the mint family traditionally used in European herbal medicine for anxiety and sleep disturbance. The 10:1 extract concentration means each 150mg is equivalent to 1,500mg of whole herb, delivering meaningful GABA-supportive and mildly sedative effects that ease the transition from stressed to settled.

Vitamin B6 (as Pyridoxal-5-Phosphate) — 10mg The active form of B6, P5P is directly involved in serotonin and GABA synthesis. Chronic stress rapidly depletes B6 stores, impairing the body's ability to produce calming neurotransmitters. Replenishing with P5P — not the cheaper pyridoxine HCl form — ensures immediate bioavailability.

Vitamin B12 (Methylcobalamin) — 500mcg Methylcobalamin is the neurologically active form of B12, supporting myelin sheath integrity, energy metabolism, and mood regulation. Stress and anxiety are strongly associated with B12 depletion, particularly in adults over 40.

Magnesium (as Glycinate) — 75mg The most bioavailable magnesium form, glycinate crosses the blood-brain barrier and directly supports GABAergic calming, muscle relaxation, and cortisol regulation. A meaningful supporting dose without causing digestive issues.

Key Benefits

• 8-ingredient clinical cortisol & stress formula

• Targets HPA axis, nervous system, cognition & nutrition simultaneously

• KSM-66® + Rhodiola + Phosphatidylserine — proven cortisol-modulating trio

• Active B vitamins (P5P + Methylcobalamin) — not cheap synthetic forms

• 90 capsules · 30-day supply (3 capsules/day)

• Allergen-free · Non-GMO · Third-party tested

• HPMC vegan capsule — no gelatin

How to Use Take 3 capsules daily with a meal. May be split into morning (2 capsules) and afternoon (1 capsule) for sustained effect throughout the day. For best results, use consistently for a minimum of 4–6 weeks. Not recommended during pregnancy or nursing without physician guidance.

Supplement Facts

Serving Size: 3 Capsules · Servings Per Container: 30

* Daily Value not established.

Other Ingredients: HPMC capsule, organic rice hull concentrate, silicon dioxide.

Free From: All common allergens · GMO · Artificial Colors · Artificial Flavors · Preservatives

🔬 Third-Party Tested for Purity, Potency & Transparency.

† These statements have not been evaluated by the Food and Drug Administration. This product is not intended to diagnose, treat, cure, or prevent any disease.